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"Lilpop, Rau i Loewenstein factory in 1865 Lilpop, Rau i Loewenstein (, often shortened to Lilpop or LRL) was a Polish engineering company. Established in 1818 as an iron foundry, with time it rose to become a large holding company specialising in iron and steel production, as well as all sorts of machinery and metal products. The largest factory was in Warsaw. Between the 1860s and World War II the company was the largest Polish producer of machinery, cars, lorries and railway equipment. The range of products designed and produced by Lilpop included train engines, rails, railway cars and equipment for railroads, automotive engines, license-built lorries (Chevrolet and Buick), steam turbines, electric appliances and many other types of machinery. The main factory of Lilpop, Rau i Loewenstein in Warsaw was looted by the Germans during World War II and the buildings demolished. The company was not rebuilt after the war. History = Early years (1818–1855) = The predecessor to the Lilpop, Rau i Loewenstein company was the Odlewnia i Rządowa Fabryka Machin ("Foundry and Government Machinery Factory"), the first iron foundry in Warsaw. Established in 1818, it was initially headed by Thomas Evans and Joseph Morris, two British nationals active in the Kingdom of Poland at the time. In 1824 Morris left the business and it was taken over by Thomas Evans and his brother Andrew, hence it was renamed to "Bracia Evans" – the Evans Brothers Co. They were later joined by Douglas Evans, Alfred Evans and engineer Joshua Routledge. The company was producing mostly cast iron agricultural equipment and had a crew of approximately 150 workers. Initially occupying a small plot of land at Piesza Street, soon it was moved to the ground of a former convent and a defrocked St. George's Church at Świętojerska Street. A modern factory, it was the first venue in Warsaw to use gas lighting. During the November Uprising the factory extended its product range to include cannons for the Polish Army. The company prospered until the outbreak of the Crimean War in 1854, when all British citizens, including Alfred and Douglas Evans, had to leave the Russian Empire and its dependencies. Soon before their departure in 1855 the Evans brothers invited two new people to the company: Wilhelm Rau and Stanisław Lilpop. Lilpop, a son of a watchmaker who had moved to Warsaw from Styria in the late 18th century, graduated from the Warsaw Piarist School in 1833 and joined the Evans Brothers company as a trainee. A promising engineer, the Bank of Poland financed a scholarship for him and he was sent to Germany, England and France to train in steam engine construction. Upon his return he took over the former State Machinery Factory (then headed by Wilhelm Rau, who continued to work for Lilpop), initially as its managing director and then as its owner. Production of various agricultural machines of his own design, notably a reaper based on William Manning's design, allowed him to gather significant wealth and soon his firm was merged with that of the Evans brothers under a new name of "Evans, Lilpop et Comp." = Rise to power (1855–1866) = A 1920s gas compressor bearing the LRL name The new company was now the first true concern in Poland: it owned not only the mechanical works in Warsaw, but also two iron ore mines and steel mills in Drzewica and Rozwady, both near Radom. Lilpop modernised the production, turning the Warsaw plant from a simple manufactory to a modern, mechanised factory. He also started cooperation with banks and introduced credit sale of his agricultural machines, a novelty in Poland at the time. By 1866 the Warsaw factory included iron and brass foundries, along with mechanical workshops, all powered by a 40-horsepower steam engine. That year the factory sold 22 steam engines and 1422 various machines for 360,000 roubles, the steel mills of Rozwady and Drzewica brought additional 300,000 in income. The crew of the factory rose from 300 to 450 workers, plus 250 working in Rozwady and Drzewica. One of the best-selling products of the company was a reaper dubbed Amerykanka – The American, based on Lilpop's earlier designs. The reaper was very successful commercially (over 90 sold between 1857 and 1863 alone) and British Ransomes & Sims bought license for its production in the United Kingdom. It received a silver medal at the 1867 International Exposition in Paris and remained in production almost until the end of the century. The company started producing equipment for railway companies, including rails and rail cars, notably for the Warsaw–Vienna railway. By 1866 Lilpop and Rau bought remaining shares of the Evans Brothers firm and renamed it to "Lilpop i Rau". Lilpop died later the same year in Biarritz, but his widow, Joanna Lilpop, took over both his shares and his seat in the board. She was the first, and for many years the only woman to hold a seat on the board of any large industrial firm in Poland. She was later joined by their sons: Karol Lilpop (1849–1924), Wiktor Lilpop (1851–1922) and Marian Lilpop (1855–1889). = Before the Great War (1866–1914) = After Lilpop's death, Bonawentura Toeplitz became the new general director and in 1868 was invited into the partnership. Loewenstein, a Jewish entrepreneur from Berlin, was both the nephew and son-in-law of Leopold Kronenberg, the richest banker, industrialist and railroad tycoon of Poland. With Kronenberg's financial support (initially direct, later through his Commercial Bank), the then- renamed Lilpop, Rau i Loewenstein company rose to become the largest industrial conglomerate of Poland, and one of largest companies of Imperial Russia. Most importantly, both Jan Gotlib Bloch and Kronenberg placed huge orders for train engines and cars at the Lilpop factory, for their ever- expanding train empires. Because of that, by 1877 Lilpop, Rau i Loewenstein was responsible for over a quarter of all industrial production of Poland. In addition, the company produced all sorts of iron and steel constructions, pipes, machinery, artillery shells, field kitchens and military equipment. 1923 stock certificate of LRL company, denominated in Polish marka A crisis came in 1877, when Russia turned to mercantilism to protect its own markets. High tariffs were imposed on import of, among others, coal, ores, iron and steel; also a customs boundary was created between Congress Poland and the rest of Russia. To counter the threat of being deprived of raw materials, in 1879 Lilpop company entered into a partnership with several bankers and turned their old iron foundry into a modern steel plant, the largest such factory in Poland. Also, a gigantic iron-rolling mill was constructed shortly afterwards. By the end of the century the total production of steel in the Kingdom of Poland rose from 18,000 tons in 1877 to 270,000 tons, with roughly a quarter produced by Lilpop, Rau i Loewenstein. In addition, the company opened new factories on the other side of the new customs boundary, in Bila Tserkva (until 1878) and Slavuta (until 1910). It also had permanent trade offices in St. Petersburg, Moscow, Tbilisi, Odessa and Baku. In 1885 the factory was electrified as one of the first buildings in Warsaw, the company also started experimenting with arc welding, a novelty at the time. By the end of the century the Warsaw plant alone had over 1300 workers. In 1905 Bonawentura Toeplitz died, having led the company for 39 years. One of his last plans, completed over the next decade, was the move of the main factory and its main offices to a new, more modern venue at Bema Street. = The last decades (1914–1945) = A license-built Chevrolet bus in Bielsko-Biała, 1937 A license-built Chevrolet Master Sedan in Poland (1936-1939) After the outbreak of World War I, in 1915 the factory, along with most of the staff (roughly 2000 workers in 1914), was evacuated to Kremenchug by tsarist authorities. There the equipment of the factory was captured by the Reds in the course of the Russian Civil War and only a small part was brought back to Warsaw after the Polish-Soviet War and the Peace of Riga. The factory in Warsaw was nevertheless rebuilt and continued to prosper as one of principal industrial centres of the country. Between 1921 and 1931 the factory was modernised and further expanded, extending the line of products by addition of internal combustion engines. The Lilpop factory produced train engines, railway and tramway cars, bus bodies, lorry undercarriages (in cooperation with Hanomag), water turbines, industrial washing machines, rotodynamic pumps and many other products. In 1925 Lilpop factory introduced the Lilpop C electric tram, a reverse-engineered and slightly improved version of the ageing Typ A tram by a German consortium including Van der Zyper & Charlier, Siemens-Schuckert, MAN and Falkenried companies. While based on a tram introduced 20 years before, the C type (bought in small numbers by the city of Warsaw) became the first in a long line of modern trams based on it, starting with Lilpop I (1927), Lilpop II and Lilpop LRL (1929), Lilpop G (1932) and Lilpop III (1939). The trams were in use in Łódź until 1973, some were also bought by other cities. In 1936 Lilpop also entered the automotive industry. In the early 1930s the state- owned Państwowe Zakłady Inżynieryjne (PZInż) holding had a virtual state- imposed monopoly on assembling cars. The monopoly was lifted in 1936 and Lilpop immediately signed a contract with General Motors and Opel to assemble cars in their Warsaw and Lublin factories. The decision to lift the monopoly led to entire leadership of PZInż resigning their positions. In late 1930s LRL produced a number of General Motors vehicles, the most popular being Chevrolet 1.5 and 3 ton trucks Car production at Lilpop started less than a year later, with a large portfolio of locally assembled cars. Among them were passenger cars of several brands: Buick (41 and 90), Chevrolet (Master, Imperial, and Sedan Taxi), Opel (P4, Kadett, and Olimpia). In addition, the company offered a number of utility cars and lorries, including Chevrolet's 112 van, 121, 131 and 157 truck, and 183 bus. Between the world wars, Poland was primarily an agricultural country, with an underdeveloped road network and high luxury taxes on cars. Because of that the overall volume of production remained low, with roughly 7000 cars and lorries assembled in Poland during 1938-1939. Most of these were assembled by Lilpop. In 1938 the factory had 3900 workers. The same year the management started construction of a new car factory in Lublin that was to be completed in 1940 and was to take over the automotive part of the production. However, the war started before it could be completed. During World War II the factory was taken over by Germany and assigned to Reichswerke Hermann Göring and continued the production, this time for the Wehrmacht. When the Warsaw Uprising broke out in 1944, the machinery was dismantled and sent to Germany, along with most of the workers. Perhaps the single best-known car produced by LRL was a Chevrolet 157 3-ton truck named Kubuś, converted to an improvised armoured personnel carrier during the uprising. After the uprising the factory was levelled with explosives by German troops, along with rest of the city. Only the office buildings survived the war. Legacy After the war the new communist authorities of Poland nationalised virtually all privately held companies and there was no chance to rebuild the Lilpop, Rau i Loewenstein company as a private venture. The remaining buildings at Bema Street continue to be used as offices. Perhaps the only part of the once powerful LRL concern that still exists is the Fabryka Samochodów Ciężarowych, the Lublin automotive branch of Lilpop, that was rebuilt after the war and continues to produce cars, notably the Tarpan Honker truck used by the Polish Army. Another part of the pre-war concern that continued production after the war was FSC Star, until 1939 a partially owned subsidiary producing truck components for Lilpop-made Chevrolets. Throughout its existence, the Lilpop, Rau i Loewenstein company also trained many of the most important Polish engineers. Among those who collaborated with the company were Karol Adamiecki and the pioneer of arc welding Stanisław Olszewski. However, one of the best- known workers of Lilpop is Bolesław Prus, the famous Polish writer, who worked there for several years as an office clerk. See also * K. Rudzki i S-ka Notes References * Manufacturing companies based in Warsaw Manufacturing companies disestablished in 1945 1945 disestablishments in Poland Manufacturing companies established in 1818 1818 establishments in Poland "
"Intravascular hemolysis describes hemolysis that happens mainly inside the vasculature. As a result, the contents of the red blood cell are released into the general circulation, leading to hemoglobinemia and increasing the risk of ensuing hyperbilirubinemia. Mechanism Intravascular hemolysis is the state when the red blood cell ruptures as a result of the complex of complement autoantibodies attached (fixed) on the surfaces of RBCs attack and rupture RBCs' membranes, or a parasite such as Babesia exits the cell that ruptures the RBC's membrane as it goes. Upon RBC's rupture, components of which are released and circulating in the blood plasma. These components comprise hemoglobin and others. At this stage, the hemoglobin is called free hemoglobin. Free hemoglobin (also called naked hemoglobin) is the un-bound hemoglobin that is not enclosed in the red blood cell. The naked hemoglobin is devoid of its anti-oxidant sentries that are normally available within the RBC. Free hemoglobin is thus vulnerable to be oxidized. When the serum concentration of free hemoglobin is within the physiologic range of haptoglobin, the potential deleterious effects of free hemoglobin are prevented because haptoglobin will bind to "free hemoglobin" forming a complex of "free hemoglobin-haptoglobin" evidenced by reduced amount of haptoglobin. However, during hyper-hemolytic conditions or with chronic hemolysis, haptoglobin is depleted so the remaining free hemoglobin readily distribute to tissues where it might be exposed to oxidative conditions, thus some of the ferrous heme (FeII), the oxygen-binding component of hemoglobin, of the free hemoglobin are oxidized and becoming met-hemoglobin (ferric hemoglobin). In such conditions, heme along with globin chains can be released from further oxidization of met-hemoglobin (ferric Hb). In which, the free heme can then accelerate tissue damage by promoting peroxidative reactions and activation of inflammatory cascades. At this time, hemopexin, another plasma glycoprotein come to bind with heme with its privilege of high heme affinity, forming a complex of heme-hemopexin, which is non-toxic, and travel together to a receptor on hepatocytes and macrophages within the spleen, liver and bone marrow. (Note that the "free hemoglobin-haptoglobin" complex is taken up by hepatocytes and, to the lesser extent, macrophages.) Thereafter, these complexes will undergo the metabolic mechanisms like extravascular hemolysis. Nevertheless, if the binding capacities of haptoglobin and hemopexin are saturated, the remaining "free hemoglobin" in the plasma will be oxidized to met-hemoglobin eventually, and then further disassociates into free heme and others. At this stage, the "free heme" will bind to albumin, forming met- hemalbumin. As to the remaining unbound (met)hemoglobin is filtered into the primary urine and re-absorbed via proximal tubules of the kidney. In proximal tubules, the iron is extracted and stored as hemosiderin. (Long-term hemoglobinuria is associated with substantial deposition of hemosiderin in proximal tubule (excessive accumulation of hemosiderin in proximal tubule), Fanconi syndrome (damaged renal re-absorption capability of small molecules which give rises to hyper-aminoaciduria, glycosuria, hyperphosphaturia, and bicarbonate and dehydration), and chronic kidney failure.) In the end, if the plasma concentration of the "free met-hemoglobin" and/or "free hemoglobin" is still too high for proximal tubule to absorb back into the body, then hemoglobinuria occurs, indicating an extensive intravascular hemolysis. These remaining free hemoglobin entities also begin to consume nitric oxide, which is critical regulators of vascular homeostasis and basal and stress-mediated smooth muscle relaxation and vasomotor tone, endothelial adhesion molecule expression, and platelet activation and aggregation. The reduction of nitric oxide deeply disturbs the body's mechanism to maintain the stability of the hemodynamics. Additionally, free hemoglobin manifests direct cytotoxic, inflammatory, and pro-oxidant effects that in turn negatively impact endothelial function. At the meantime, free heme exerts its multiple pro- inflammatory and pro-oxidant effects to the tissues it goes through. It is important to note that although hemosiderins are also included in the urine in the setting of intravascular hemolytic hemoglobinuria, it will be detected only several days after the onset of the extensive intravascular hemolysis and will remain detectable several days after termination of intravascular hemolysis. The phenomenon tells that the detection of hemosiderin in urine is indicative of either ongoing or recent intravascular hemolysis characterized by excessive hemoglobin and/or met-hemoglobin filtered through the renal glomerulus as well as the loss of hemosiderin-laden necrotic tubular cells. Note References Hematology Hemoglobins "
"Fat Kid Rules the World is a 2012 comedy-drama film directed by Matthew Lillard in his directorial debut. It is based on the book of the same name and stars Jacob Wysocki, Matt O'Leary & Billy Campbell. Plot 17-year-old Troy Billings is overweight and suicidal. He's saved by Marcus from jumping in front of a bus and begins an uneasy friendship with Marcus. Marcus then enlists the musically challenged Troy to become the drummer in a new punk rock band. As Troy's relationship with Marcus grows, Troy's father becomes increasingly concerned about his son's new friendship. Cast *Jacob Wysocki as Troy *Matt O'Leary as Marcus *Billy Campbell as Mr. Billings *Dylan Arnold as Dayle *Tyler Trerise as Manoj *Russell Hodgkinson as Marcus' Stepfather *Julian Gavilanes as Matt *Sean Donavan as Ollie *Lili Simmons as Isabel *Jeffrey Doornbos as Mr. Sherman *Matthew Lillard as Guidance Counsellor Reception Fat Kid Rules the World received positive reviews from critics and audiences, earning an 83% approval rating on Rotten Tomatoes. External links 2012 films Films based on American novels American films American comedy-drama films "